PD-1/PD-L1 Blockade Therapy for Tumors with Downregulated MHC Class I Expression
Author:
Funder
Czech Science Foundation
Publisher
MDPI AG
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Link
http://www.mdpi.com/1422-0067/18/6/1331/pdf
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4. Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
5. SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
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