Prognostic Value of Cheyne-Stokes Respiration and Nutritional Status in Acute Decompensated Heart Failure

Author:

Abulimiti Abidan1ORCID,Naito Ryo123,Kasai Takatoshi1234ORCID,Ishiwata Sayaki123,Nishitani-Yokoyama Miho1,Sato Akihiro12,Suda Shoko13,Matsumoto Hiroki1,Shitara Jun1,Yatsu Shoichiro1,Murata Azusa1,Shimizu Megumi1ORCID,Kato Takao1ORCID,Hiki Masaru1,Daida Hiroyuki15,Minamino Tohru16

Affiliation:

1. Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan

2. Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan

3. Sleep and Sleep-Disordered Breathing Center, Juntendo University Hospital, Tokyo 113-8421, Japan

4. Department of Cardiovascular Management and Remote Monitoring, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan

5. Faculty of Health Science, Juntendo University, Tokyo 113-8421, Japan

6. Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo 113-8421, Japan

Abstract

Malnutrition frequently coexists with heart failure (HF), leading to series of negative consequences. Cheyne–Stokes respiration (CSR) is predominantly detected in patients with HF. However, the effect of CSR and malnutrition on the long-term prognosis of patients with acute decompensated HF (ADHF) remains unclear. We enrolled 162 patients with ADHF (median age, 62 years; 78.4% men). The presence of CSR was assessed using polysomnography and the controlling nutritional status score was assessed to evaluate the nutritional status. Patients were divided into four groups based on CSR and malnutrition. The primary outcome was all-cause mortality. In total, 44% of patients had CSR and 67% of patients had malnutrition. The all-cause mortality rate was 26 (16%) during the 35.9 months median follow-up period. CSR with malnutrition was associated with lower survival rates (log-rank p < 0.001). Age, hemoglobin, albumin, lymphocyte count, total cholesterol, triglyceride, low-density lipoprotein cholesterol, creatinine, estimated glomerular filtration rate, B-type natriuretic peptide, administration of loop diuretics, apnea-hypopnea index and central apnea-hypopnea index were significantly different among all groups (p < 0.05). CSR with malnutrition was independently associated with all-cause mortality. In conclusion, CSR with malnutrition is associated with a high risk of all-cause mortality in patients with ADHF.

Funder

Grant-in-Aid for Scientific Research

JSPS KAKENHI

Ministry of Health, Labor and Welfare

Japanese Center for Research on Women in Sport, Juntendo University

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference35 articles.

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