Polyketide Derivatives from the Mangrove-Derived Fungus Penicillium sp. HDN15-312-Reference-Cited by-同舟云学术

Polyketide Derivatives from the Mangrove-Derived Fungus Penicillium sp. HDN15-312

Published:2024-08-08 Issue:8 Volume:22 Page:360
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Liu Fuhao¹,Wang Wenxue¹^ORCID,Wang Feifei¹,Zhou Luning¹,Luo Guangyuan¹,Zhang Guojian¹²^ORCID,Zhu Tianjiao¹^ORCID,Che Qian¹^ORCID,Li Dehai¹²³^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

2. Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China

3. Sanya Oceanographic Institute, Ocean University of China, Sanya 572025, China

Abstract

Four new polyketides, namely furantides A–B (1–2), talamin E (3) and arugosinacid A (4), and two known polyketides were obtained from the mangrove-derived fungus Penicillium sp. HDN15-312 using the One Strain Many Compounds (OSMAC) strategy. Their chemical structures, including configurations, were elucidated by detailed analysis of extensive NMR spectra, HRESIMS and ECD. The DPPH radicals scavenging activity of 3, with an IC50 value of 6.79 µM, was better than vitamin C.

Funder

National Key Research and Development Program of China

Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City

Fundamental Research Funds for the Central Universities

Shandong Provincial Natural Science Foundation

Publisher

MDPI AG

Link

https://www.mdpi.com/1660-3397/22/8/360/pdf

Reference23 articles.

1. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases;Phaniendra;India J. Clin. Biochem.,2015

2. Impact of Oxidative Stress on Inflammation in Rheumatoid and Adjuvant Arthritis: Damage to Lipids, Proteins, and Enzymatic Antioxidant Defense in Plasma and Different Tissues;Ponist;Anim. Models Exp. Med.,2019

3. Free Radicals, Antioxidants and Functional Foods: Impact on Human Health;Lobo;Pharmacogn. Rev.,2010

4. Iron in Multiple Sclerosis: Roles in Neurodegeneration and Repair;Stephenson;Nat. Rev. Neurol.,2014

5. Conti, V., Izzo, V., Corbi, G., Russomanno, G., Manzo, V., De Lise, F., Di Donato, A., and Filippelli, A. (2016). Antioxidant Supplementation in the Treatment of Aging-Associated Diseases. Front. Pharmacol., 7.