Affiliation:
1. School of Life Sciences, Hebei University, 180 Wusi Dong Lu, Baoding 071002, China
2. Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China
Abstract
The aging of the population is an increasingly serious issue, and many age-related illnesses are on the rise. These illnesses pose a serious threat to the health and safety of elderly individuals and create a serious economic and social burden. Despite substantial research into the pathogenesis of these diseases, their etiology and pathogenesis remain unclear. In recent decades, rodent models have been used in attempts to elucidate these disorders, but such models fail to simulate the full range of symptoms. Nonhuman primates (NHPs) are the most ideal neuroscientific models for studying the human brain and are more functionally similar to humans because of their high genetic similarities and phenotypic characteristics in comparison with humans. Here, we review the literature examining typical NHP brain disease models, focusing on NHP models of common diseases such as dementia, Parkinson’s disease, and epilepsy. We also explore the application of electroencephalography (EEG), magnetic resonance imaging (MRI), and optogenetic study methods on NHPs and neural circuits associated with cognitive impairment.
Funder
National Natural Science Foundation of China
Logistics Research Program of the Youth Cultivation Project
Equipment Research Program
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
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