Volumetric Differences in Cerebellum and Brainstem in Patients with Migraine: A UK Biobank Study

Author:

Affatato Oreste12ORCID,Rukh Gull1ORCID,Schiöth Helgi Birgir1,Mwinyi Jessica12

Affiliation:

1. Functional Pharmacology and Neuroscience Unit, Department of Surgical Science, Uppsala University, 752 36 Uppsala, Sweden

2. Uppsala University’s Centre for Women’s Mental Health during the Reproductive Lifespan—WoMHeR, Uppsala University, 752 36 Uppsala, Sweden

Abstract

Background: The cerebellum and the brainstem are two brain structures involved in pain processing and modulation that have also been associated with migraine pathophysiology. The aim of this study was to investigate possible associations between the morphology of the cerebellum and brainstem and migraine, focusing on gray matter differences in these brain areas. Methods: The analyses were based on data from 712 individuals with migraine and 45,681 healthy controls from the UK Biobank study. Generalized linear models were used to estimate the mean gray matter volumetric differences in the brainstem and the cerebellum. The models were adjusted for important biological covariates such as BMI, age, sex, total brain volume, diastolic blood pressure, alcohol intake frequency, current tobacco smoking, assessment center, material deprivation, ethnic background, and a wide variety of health conditions. Secondary analyses investigated volumetric correlation between cerebellar sub-regions. Results: We found larger gray matter volumes in the cerebellar sub-regions V (mean difference: 72 mm3, 95% CI [13, 132]), crus I (mean difference: 259 mm3, 95% CI [9, 510]), VIIIa (mean difference: 120 mm3, 95% CI [0.9, 238]), and X (mean difference: 14 mm3, 95% CI [1, 27]). Conclusions: Individuals with migraine show larger gray matter volumes in several cerebellar sub-regions than controls. These findings support the hypothesis that the cerebellum plays a role in the pathophysiology of migraine.

Funder

Uppsala University’s centre for Women’s Mental Health during the Reproductive lifespan—WoMHeR

Swedish Research Council and the Swedish Brain Foundation

Svenska Sällskapet för Medicinsk Forskning

Uppsala University

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

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