Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases

Author:

Gyorfi Nina12,Gal Adrian Robert13,Fincsur Andras4,Kalmar-Nagy Karoly5,Mintal Kitti12,Hormay Edina12,Miseta Attila6,Tornoczky Tamas4,Nemeth Anita Katalin7,Bogner Peter7,Kiss Tamas8,Helyes Zsuzsanna8910,Sari Zoltan11112,Klincsik Mihaly11112,Tadic Vladimir111314ORCID,Lenard Laszlo12,Vereczkei Andras5,Karadi Zoltan12,Vizvari Zoltan1111415ORCID,Toth Attila12

Affiliation:

1. Medical and Engineering Multidisciplinary Cellular Bioimpedance Research Group, Szentagothai Research Centre, University of Pecs, Ifjusag Str. 20, H-7624 Pecs, Hungary

2. Institute of Physiology, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

3. Department of Medical Biology and Central Electron Microscopic Laboratory, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

4. Department of Pathology, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

5. Department of Surgery, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

6. Department of Laboratory Medicine, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

7. Department of Medical Imaging, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

8. Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary

9. Eötvös Loránd Research Network, Chronic Pain Research Group, University of Pecs, H-7624 Pecs, Hungary

10. National Laboratory for Drug Research and Development, Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary

11. Symbolic Methods in Material Analysis and Tomography Research Group, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 6, H-7624 Pecs, Hungary

12. Department of Technical Informatics, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 2, H-7624 Pecs, Hungary

13. Institute of Information Technology, University of Dunaujvaros, Tancsics M. Str. 1/A, H-2401 Dunaujvaros, Hungary

14. John von Neumann Faculty of Informatics, University of Obuda, Becsi Str. 96/B, H-1034 Budapest, Hungary

15. Department of Environmental Engineering, Faculty of Engineering and Information Technology, University of Pecs, Boszorkany Str. 2, H-7624 Pecs, Hungary

Abstract

Based on a prior university patent, the authors developed a novel type of bioimpedance-based test method to noninvasively detect nonalcoholic fatty liver disease (NAFLD). The development of a new potential NAFLD diagnostic procedure may help to understand the underlying mechanisms between NAFLD and severe liver diseases with a painless and easy-to-use paraclinical examination method, including the additional function to detect even the earlier stages of liver disease. The aim of this study is to present new results and the experiences gathered in relation to NAFLD progress during animal model and human clinical trials.

Funder

University of Pécs

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Reference43 articles.

1. Non-invasive diagnosis and staging of non-alcoholic fatty liver disease;Kechagias;Hormones,2022

2. Non-alcoholic fatty liver disease—A global public health perspective;Younossi;J. Hepatol.,2019

3. Mechanisms of NAFLD development and therapeutic strategies;Friedman;Nat. Med.,2018

4. Petzold, G. (2022). Role of Ultrasound Methods for the Assessment of NAFLD. J. Clin. Med., 11.

5. The prevalence and incidence of NAFLD worldwide: A systematic review and meta-analysis;Riazi;Gastroenterol. Hepatol.,2022

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