Assessing Biocompatibility of Composite Cements by Peri/Intramuscular and Subcutaneous Implantation in Rats

Author:

Ardelean Alina Ioana1ORCID,Marza Sorin Marian2,Negoescu Andrada3,Dragomir Madalina Florina1ORCID,Sarosi Codruta4ORCID,Moldovan Marioara4ORCID,Ene Razvan56ORCID,Oana Liviu1

Affiliation:

1. Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania

2. Department of Veterinary Imagistics, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania

3. Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania

4. Department Polymeric Composites, Babeș-Bolyai University, 400294 Cluj-Napoca, Romania

5. Department Orthopedics, Anesthesia and Intensive Care, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania

6. Orthopedics and Traumatology Department, Bucharest Emergency University Hospital, 050098 Bucharest, Romania

Abstract

This study’s goal was to evaluate the biocompatibility of two composite cements over a 90-day period by analyzing the individuals’ behavior as well as conducting macroscopic and histological examinations and Computed Tomography (CT) scans. We conducted the cytotoxicity test by placing the materials subcutaneously and peri/intramuscularly. Days 30 and 90 were crucial for our research. On those days, we harvested the implants, kidneys and liver to search for any toxic deposits. The biomaterial’s uniformity, color and texture remained unaltered despite being in intimate contact with the tissue. Although a slight inflammatory response was observed in the placement location, we observed an improved outcome of the interaction between the material and its insertion area. There were no notable discoveries in the liver and kidneys. According to the obtained results, the biomaterials did not produce any clinical changes nor specific irritation during the research, demonstrating that they are biocompatible with biological tissues.

Publisher

MDPI AG

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