Sinus Floor Augmentation with Synthetic Hydroxyapatite (NanoBone®) in Combination with Platelet-Rich Fibrin: A Case Series-Reference-Cited by-同舟云学术

Sinus Floor Augmentation with Synthetic Hydroxyapatite (NanoBone®) in Combination with Platelet-Rich Fibrin: A Case Series

Published:2024-07-25 Issue:8 Volume:12 Page:1661
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Francisco Luís¹^ORCID,Francisco Manuel²^ORCID,Costa Rosana¹³^ORCID,Vasques Miguel¹³,Relvas Marta¹³^ORCID,Rajão António⁴⁵^ORCID,Monteiro Luís¹³^ORCID,Rompante Paulo¹^ORCID,Guerra Fernando⁶⁷⁸^ORCID,Infante da Câmara Marco¹³⁹^ORCID

Affiliation:

1. Oral Pathology and Rehabilitation Research Unit (UNIPRO), University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal

2. Clinical Assistant Professor Postgraduate Implant Program, Famalicão Unit, University Institute of Health Sciences (IUCS-CESPU), Av. Marechal Humberto Delgado, 14, 4760-012 Vila Nova de Famalicão, Portugal

3. Department of Medicine and Oral Surgery, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal

4. Associate Laboratory i4HB—Institute for Health and Bioeconomy, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal

5. Applied Molecular Biosciences Unit (UCIBIO), Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal

6. Institute of Oral Implantology and Prosthodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal

7. Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal

8. Laboratory of Hard Tissues, Dentistry Department, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal

9. Coordinator of the Postgraduate Implant Program, Famalicão Unit, University Institute of Health Sciences (IUCS-CESPU), Av. Marechal Humberto Delgado, 14, 4760-012 Vila Nova de Famalicão, Portugal

Abstract

Several techniques have been described for maxillary sinus graft augmentation, including the lateral window technique and crestal approach with osteotomes or osseodensification. Platelet-rich fibrin has been used in maxillary sinus lift procedures due to its ability to accelerate soft and hard tissue healing. The aim of this study was to evaluate the potential of PRF in combination with the synthetic hydroxyapatite NanoBone® to enhance bone regeneration in sinus floor elevation with the lateral window technique. Out of the 50 individuals screened in a preoperative assessment visit from the CESPU—Famalicão clinical unit and intervened upon between January 2023 and December 2023, only 6 patients who met the study’s inclusion criteria consented to participate. In a split-mouth study, twelve sinus graft surgeries were carried out. Our observations reveal that for the test group (NanoBone®/PRF), there is a 27.5 ± 4.9% increase new vital bone, 23.0 ± 3.7% increase in inert bone particles, and 49.4 ± 2.8% increase in connective tissue. Meanwhile, for the control group (NanoBone®), there is a 19.5 ± 3.0% increase in new vital bone, 23.4 ± 5.7% increase in inert bone particles, and 57.0 ± 3.5% increase in connective tissue. The results strongly indicate that mixing liquid PRF with NanoBone® does not have a negative influence on the amount of viable bone formation, and it seems to slightly increase the amount of new bone formation and revascularization in sinus bone graft procedures with the lateral window technique compared to the single use of NanoBone®.

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-9059/12/8/1661/pdf

Reference32 articles.

1. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift;Choukroun;Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.,2006

2. Update of Surgical Techniques for Maxillary Sinus Augmentation: A Systematic Literature Review;Perrotti;Implant Dent.,2016

3. Sinus floor elevation procedures to enable implant placement and integration: Techniques, biological aspects and clinical outcomes;Lundgren;Periodontol. 2000,2017

4. Fontes Pereira, J., Costa, R., Nunes Vasques, M., Salazar, F., Mendes, J.M., and Infante da Câmara, M. (2023). Osseodensification: An Alternative to Conventional Osteotomy in Implant Site Preparation: A Systematic Review. J. Clin. Med., 12.

5. Fukuba, S., Okada, M., Nohara, K., and Iwata, T. (2021). Alloplastic bone substitutes for periodontal and bone regeneration in dentistry: Current status and prospects. Materials, 14.