The Impact of Autosomal Dominant Polycystic Kidney Disease in Children: A Nephrological, Nutritional, and Psychological Point of View-Reference-Cited by-同舟云学术

The Impact of Autosomal Dominant Polycystic Kidney Disease in Children: A Nephrological, Nutritional, and Psychological Point of View

Published:2024-08-12 Issue:8 Volume:12 Page:1823
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Guarnaroli Matteo¹,Padoan Flavia¹,Fava Cristiano²^ORCID,Benetti Maria Giulia¹,Brugnara Milena¹,Pietrobelli Angelo¹^ORCID,Piacentini Giorgio¹,Pecoraro Luca¹^ORCID

Affiliation:

1. Pediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37126 Verona, Italy

2. General Medicine and Hypertension Unit, Department of Medicine, University of Verona, 37126 Verona, Italy

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by the formation of numerous fluid-filled cysts in the kidneys, leading to progressive renal failure and various extrarenal complications, including hypertension. This review explores the genetic basis of ADPKD, including emerging evidence of epigenetic mechanisms in modulating gene expression and disease progression in ADPKD. Furthermore, it proposes to examine the pathological characteristics of this condition at the nephrological, cardiovascular, nutritional, and psychological levels, emphasizing that the follow-up of patients with ADPKD should be multidisciplinary from a young pediatric age.

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-9059/12/8/1823/pdf

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