Author:
Maor Yaakov,Ergaz David,Malnick Stephen D. H.,Melzer Ehud,Neuman Manuela G.
Abstract
A 52-year-old woman with a BMI of 31.2 kg/m2 was treated with the glucagon-like peptide 1 (GLP-1) agonist liraglutide as part of her weight-reduction program. Following this, she developed an idiosyncratic drug-related liver injury (IDILI). Advances in noninvasive techniques enabled this diagnosis to be established. By employing easily quantifiable methods based on serum biomarkers, we could explore a wide variety of endpoints in assessing personalized DILI. In addition, we can test endpoints that are associated with the drug’s mechanism of action. Personalized medicine and therapeutic pharmacovigilance of incretin-based hypoglycemic agents are needed to ensure the safety of patients.
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Cited by
11 articles.
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