Potential Impact of a Pregnant Woman’s Microbiota on the Development of Fetal Heart Defects: A Review of the Literature

Author:

Zych-Krekora Katarzyna1ORCID,Sylwestrzak Oskar23,Krekora Michał24,Oszukowski Przemysław56,Grzesiak Mariusz14ORCID

Affiliation:

1. Department of Perinatology, Obstetrics and Gynaecology, Polish Mother’s Memorial Hospital Research Institute, 93-338 Lodz, Poland

2. Department of Obstetrics and Gynaecology, Polish Mother’s Memorial Health Institute, 93-338 Lodz, Poland

3. Department of Prenatal Cardiology, Polish Mother’s Memorial Hospital Research Institute, 93-338 Lodz, Poland

4. Department of Gynaecology and Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland

5. Obstetrics Ward of the Polish Mother’s Memorial Health Institute, 93-338 Lodz, Poland

6. Department of Obstetrics, Gynaecology and Gynaecology Oncology, Medical University of Lodz, 93-113 Lodz, Poland

Abstract

Developments in medicine and biology in recent decades have led to a significant increase in our knowledge of the complex interactions between the microbiota and human health. In the context of perinatal medicine and neonatology, particular attention is being paid to the potential impact of the maternal microbiota on fetal development. Among the many aspects of this relationship, the question of the impact of dysbiosis on the development of fetal heart defects is an important one. In this article, we present an analysis of recent research and scientific evidence on the relationship between a pregnant woman’s microbiota and the development of fetal heart defects. We also discuss potential intervention strategies, including the role of probiotics and diet in optimising the maternal microbiota.

Funder

Polish Mother’s Memorial Health Institute

Publisher

MDPI AG

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