Pathophysiology-Based Management of Secondary Injuries and Insults in TBI-Reference-Cited by-同舟云学术

Pathophysiology-Based Management of Secondary Injuries and Insults in TBI

Published:2024-02-26 Issue:3 Volume:12 Page:520
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

de Macedo Filho Leonardo¹^ORCID,Figueredo Luisa F.²^ORCID,Villegas-Gomez Gustavo Adolfo³^ORCID,Arthur Matthew²^ORCID,Pedraza-Ciro Maria Camila⁴,Martins Henrique⁵,Kanawati Neto Joaquim⁵,Hawryluk Gregory J.⁶,Amorim Robson Luís Oliveira⁵⁷

Affiliation:

1. Neurosurgery Department, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA

2. Department of Psychiatry, NYU Langone Health, New York, NY 10016, USA

3. Faculty of Medicine, Universidad de Los Andes, Bogota 111711, Colombia

4. Faculty of Medicine, Universidad El Bosque, Bogota 11001, Colombia

5. Postgraduate Program in Health Sciences, Federal University of Amazonas, Manaus 69067-005, Brazil

6. Department of Neurosurgery, Cleveland Clinic and Akron General Hospital, Fairlawn, OH 44307, USA

7. Division of Neurological Surgery, Hospital das Clinicas, University of São Paulo School of Medicine, São Paulo 05508-070, Brazil

Abstract

Traumatic Brain Injury (TBI) remains a leading cause of morbidity and mortality among all ages; despite the advances, understanding pathophysiological responses after TBI is still complex, involving multiple mechanisms. Previous reviews have focused on potential targets; however, the research on potential targets has continuously grown in the last five years, bringing even more alternatives and elucidating previous mechanisms. Knowing the key and updated pathophysiology concepts is vital for adequate management and better outcomes. This article reviews the underlying molecular mechanisms, the latest updates, and future directions for pathophysiology-based TBI management.

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-9059/12/3/520/pdf

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