Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss-Reference-Cited by-全球学者库

Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss

Published:2023-12-18 Issue:12 Volume:11 Page:3347
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Lye Joey¹²^ORCID,Delaney Derek S.¹³^ORCID,Leith Fiona K.¹²,Sardesai Varda S.¹,McLenachan Samuel⁴⁵,Chen Fred K.⁴⁵⁶⁷⁸,Atlas Marcus D.¹²,Wong Elaine Y. M.¹²⁹

Affiliation:

1. Hearing Therapeutics, Ear Science Institute Australia, Nedlands, WA 6009, Australia

2. Centre for Ear Sciences, Medical School, The University of Western Australia, Nedlands, WA 6009, Australia

3. Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia

4. Ocular Tissue Engineering Laboratory, Lions Eye Institute, Nedlands, WA 6009, Australia

5. Centre for Ophthalmology and Visual Sciences, The University of Western Australia, Nedlands, WA 6009, Australia

6. Vitroretinal Surgery, Royal Perth Hospital, Perth, WA 6000, Australia

7. Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC 3002, Australia

8. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia

9. Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA 6102, Australia

Abstract

Up to 1.5 billion people worldwide suffer from various forms of hearing loss, with an additional 1.1 billion people at risk from various insults such as increased consumption of recreational noise-emitting devices and ageing. The most common type of hearing impairment is sensorineural hearing loss caused by the degeneration or malfunction of cochlear hair cells or spiral ganglion nerves in the inner ear. There is currently no cure for hearing loss. However, emerging frontier technologies such as gene, drug or cell-based therapies offer hope for an effective cure. In this review, we discuss the current therapeutic progress for the treatment of hearing loss. We describe and evaluate the major therapeutic approaches being applied to hearing loss and summarize the key trials and studies.

Funder

Australian government National Health and Medical Research Council (NHMRC) Medical Research Future Fund (MRFF) Stem Cell Therapies Mission Grant

Commonwealth Scientific and Industrial Research Organisation

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.mdpi.com/2227-9059/11/12/3347/pdf

Reference169 articles.

1. The world report on hearing, 2021;Chadha;Bull World Health Organ.,2021

2. The Societal Costs of Severe to Profound Hearing Loss in The United States;Mohr;Int. J. Technol. Assess. Health Care,2001

3. Direct Health Expenditure Analysis Related to Hearing Loss in Individuals Using Hearing Aids and Cochlear Implants;Deniz;Turk. Arch. Otorhinolaryngol.,2022

4. The impact of hearing loss on the quality of life of elderly adults;Ciorba;Clin. Interv. Aging,2012

5. Idstad, M., Tambs, K., Aarhus, L., and Engdahl, B.L. (2019). Childhood sensorineural hearing loss and adult mental health up to 43 years later: Results from the HUNT study. BMC Public. Health, 19.