Affiliation:
1. Laboratory of Human Molecular Genetics, National Research Center “Kurchatov Institute”, Kurchatov Sq. 2, 123182 Moscow, Russia
Abstract
Complex diseases that affect the functioning of the central nervous system pose a major problem for modern society. Among these, ischemic stroke (IS) holds a special place as one of the most common causes of disability and mortality worldwide. Furthermore, Alzheimer’s disease (AD) ranks first among neurodegenerative diseases, drastically reducing brain activity and overall life quality and duration. Recent studies have shown that AD and IS share several common risk and pathogenic factors, such as an overlapping genomic architecture and molecular signature. In this review, we will summarize the genomics and RNA biology studies of IS and AD, discussing the interconnected nature of these pathologies. Additionally, we highlight specific genomic points and RNA molecules that can serve as potential tools in predicting the risks of diseases and developing effective therapies in the future.
Funder
Russian Science Foundation
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference199 articles.
1. Incremental Medical Cost of Delirium in Elderly Patients with Cognitive Impairment: Analysis of a Nationwide Administrative Database in Japan;Igarashi;BMJ Open,2022
2. Declínio Cognitivo Subjetivo, Comprometimento Cognitivo Leve e Demência—Diagnóstico Sindrômico: Recomendações Do Departamento Científico de Neurologia Cognitiva e Do Envelhecimento Da Academia Brasileira de Neurologia;Smid;Dement. Neuropsychol.,2022
3. Epidemiology and the Global Burden of Stroke;Mukherjee;World Neurosurg.,2011
4. GBD 2019 Stroke Collaborators (2021). Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019. Lancet Neurol, 12, 941–948.
5. Alzheimer’s Disease: Epidemiology and Clinical Progression;Byrnes;Neurol. Ther.,2022