Author:
Bkaily Ghassan,Simon Yanick,Jazzar Ashley,Najibeddine Houssein,Normand Alexandre,Jacques Danielle
Abstract
Our knowledge on essential hypertension is vast, and its treatment is well known. Not all hypertensives are salt-sensitive. The available evidence suggests that even normotensive individuals are at high cardiovascular risk and lower survival rate, as blood pressure eventually rises later in life with a high salt diet. In addition, little is known about high sodium (Na+) salt diet-sensitive hypertension. There is no doubt that direct and indirect Na+ transporters, such as the Na/Ca exchanger and the Na/H exchanger, and the Na/K pump could be implicated in the development of high salt-induced hypertension in humans. These mechanisms could be involved following the destruction of the cell membrane glycocalyx and changes in vascular endothelial and smooth muscle cells membranes’ permeability and osmolarity. Thus, it is vital to determine the membrane and intracellular mechanisms implicated in this type of hypertension and its treatment.
Funder
Natural Sciences and Engineering Research Council of Canada
Canadian Institutes of Health Research
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Cited by
9 articles.
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