Short-Term Clinical Assessment of Treating Female Androgenetic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles
-
Published:2024-01-11
Issue:1
Volume:12
Page:153
-
ISSN:2227-9059
-
Container-title:Biomedicines
-
language:en
-
Short-container-title:Biomedicines
Author:
Krefft-Trzciniecka Katarzyna1,
Piętowska Zuzanna1ORCID,
Pakiet Alicja1,
Nowicka Danuta1,
Szepietowski Jacek C.1ORCID
Affiliation:
1. Department of Dermatology, Venereology and Allergology, Wrocław Medical University, 50-368 Wrocław, Poland
Abstract
Background: Androgenetic alopecia (AGA) is the most common form of alopecia, but treatment options are limited. This study evaluated clinical improvement in hair condition in women with AGA six months after a single injection of autologous cell micrografts (ACMs) containing hair follicle stem cells and dermal papilla cells. Methods: Twenty-three women with clinically and dermoscopy-confirmed AGA were included. Five 2.5 mm punch biopsies were taken from the skin of each patient with the Regenera device. The cell suspension was prepared with the Rigeneracons device and then injected into the hormone-dependent hairy zone of the scalp. Results: A significant improvement was observed on the visual analog scale (VAS) when comparing pre- and post-procedure photos (p < 0.001). The change in VAS scores was moderately negatively correlated with baseline ferritin concentration and positively with iron concentration. Improved outcomes were associated with higher baseline levels of sex hormone-binding globulin and 17α-hydroxyprogesterone. Neither testosterone nor DHT showed a significant correlation with VAS scores. Conclusions: The ACM procedure was shown to be both safe and effective, yielding satisfying results six months after a single treatment session. Future investigations should aim to gather evidence that enables the development of a cost-effective approach while minimizing treatment burden and costs.
Funder
Department of Dermatology, Venereology, and Allergology at Wrocław Medical University
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference47 articles.
1. Androgenetic alopecia;Piraccini;G. Ital. Dermatol. Venereol. Organo Uff. Soc. Ital. Dermatol. Sifilogr.,2014
2. Cellular Senescence: Ageing and Androgenetic Alopecia;Deng;Dermatology,2023
3. The inheritance of common baldness: Two B or not two B?;Happle;J. Am. Acad. Dermatol.,1984
4. Androgenetic Alopecia in Women;Price;J. Investig. Dermatol. Symp. Proc.,2003
5. Cyclic dynamics of hair follicles and the effect of minoxidil on the bald scalps of stumptailed macaques;Uno;Am. J. Dermatopathol.,1985