Computational Mechanics of Form-Fitting 3D-Printed Lattice-Based Wrist-Hand Orthosis for Motor Neuron Disease

Author:

Badini Silvia1,Regondi Stefano12,Lammi Carmen3ORCID,Bollati Carlotta3,Donvito Giordana1,Pugliese Raffaele1ORCID

Affiliation:

1. Nemolab, ASST GOM Niguarda Cà Granda Hospital, 20162 Milan, Italy

2. NEuroMuscular Omnicenter (NEMO), 20162 Milan, Italy

3. Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy

Abstract

Motor neuron disease (MND) patients often experience hand-wrist muscle atrophy resulting in severe social consequences and hampering their daily activities. Although hand-wrist orthosis is commonly used to assist weakened muscles, its effectiveness is limited due to the rapid progression of the disease and the need for customization to suit individual patient requirements. To address these challenges, this study investigates the application of three-dimensional (3D) printing technology to design and fabricate two lattice structures inspired by silkworm cocoons, using poly-ε-caprolactone as feedstock material. Finite element method (FEM) analysis is employed to study the mechanical behavior, enabling control over the geometric configuration incorporated into the hand-wrist orthosis. Through tensile displacement and three-point bending simulations, the stress distribution is examined for both lattice geometries. Geometry-1 demonstrates anisotropic behavior, while geometry-2 exhibits no strict directional dependence due to its symmetry and uniform node positioning. Moreover, the biocompatibility of lattices with human skin fibroblasts is investigated, confirming excellent biocompatibility. Lastly, the study involves semi-structured interviews with MND patients to gather feedback and develop prototypes of form-fitting 3D-printed lattice-based hand-wrist orthosis. By utilizing 3D printing technology, this study aims to provide customized orthosis that can effectively support weakened muscles and reposition the hand for individuals with MND.

Funder

Regione Lombardia and Unioncamere Lombardia

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Exploring a Novel Material and Approach in 3D-Printed Wrist-Hand Orthoses;Journal of Manufacturing and Materials Processing;2024-02-05

2. A Review on Wearable Product Design and Applications;Machines;2024-01-16

3. Influence of post-processing treatment on the surface roughness of polyamide PA12 samples manufactured using additive methods in the context of the production of orthoses;Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture;2023-11-03

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