Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series-Reference-Cited by-同舟云学术

Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series

Published:2023-06-24 Issue:7 Volume:11 Page:1809
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Canarutto Daniele¹²³^ORCID,Oltolini Chiara⁴,Barzaghi Federica²³,Calbi Valeria²³,Migliavacca Maddalena²³,Tucci Francesca²³^ORCID,Gallo Vera²³,Consiglieri Giulia²³,Ferrua Francesca²³,Recupero Salvatore²³,Cervi Maria Celia⁵,Al-Mousa Hamoud⁶,Pituch-Noworolska Anna⁷,Tassan Din Chiara⁴,Scarpellini Paolo⁴,Silvani Paolo⁸,Fossati Claudia²,Casiraghi Miriam²,Cirillo Daniela Maria⁹^ORCID,Castagna Antonella¹⁴,Bernardo Maria Ester¹²³,Aiuti Alessandro¹²³,Cicalese Maria Pia¹²³

Affiliation:

1. Faculty of Medicine and Surgery, Vita-Salute S. Raffaele University, 20132 Milan, Italy

2. San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

3. Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

4. Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

5. Pediatric Infectious Diseases Division, Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo 05508-000, Brazil

6. Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia

7. Department of Immunology, University Children’s Hospital, 30-663 Krakow, Poland

8. Department of Anesthesia and Critical Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

9. Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

Abstract

Vaccination with Bacillus Calmette–Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID). BCG vaccination resulted in a very high incidence of complications due to uncontrolled replication of the mycobacterium. All patients who developed BCG-related disease were treated successfully and remained free from recurrence of disease. We recommend the prompt initiation of enzyme replacement therapy and secondary prophylaxis to reduce the risk of BCG-related complications in ADA-SCID patients.

Funder

Fondazione Telethon

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.mdpi.com/2227-9059/11/7/1809/pdf

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