Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery

Author:

Hou Xiaolin1,Li Jiaqi1,Hong Yongyu2,Ruan Hang1,Long Meng1,Feng Nianping1ORCID,Zhang Yongtai1ORCID

Affiliation:

1. Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Pudong New Area, Shanghai 201203, China

2. Xiamen Hospital of Chinese Medicine, No. 1739 Xiangyue Road, Huli District, Xiamen 361015, China

Abstract

Transdermal drug delivery (TDD) is one of the key approaches for treating diseases, avoiding first-pass effects, reducing systemic adverse drug reactions and improving patient compliance. Microneedling, iontophoresis, electroporation, laser ablation and ultrasound facilitation are often used to improve the efficiency of TDD. Among them, microneedling is a relatively simple and efficient means of drug delivery. Microneedles usually consist of micron-sized needles (50–900 μm in length) in arrays that can successfully penetrate the stratum corneum and deliver drugs in a minimally invasive manner below the stratum corneum without touching the blood vessels and nerves in the dermis, improving patient compliance. Hydrogel-forming microneedles (HFMs) are safe and non-toxic, with no residual matrix material, high drug loading capacity, and controlled drug release, and they are suitable for long-term, multiple drug delivery. This work reviewed the characteristics of the skin structure and TDD, introduced TDD strategies based on HFMs, and summarized the characteristics of HFM TDD systems and the evaluation methods of HFMs as well as the application of HFM drug delivery systems in disease treatment. The HFM drug delivery system has a wide scope for development, but the translation to clinical application still has more challenges.

Funder

National Natural Science Foundation of China

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Program for Shanghai High-Level Local University Innovation Team

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

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