The Current Status of Molecular Biomarkers for Inflammatory Bowel Disease

Author:

Alghoul Zahra,Yang ChunhuaORCID,Merlin Didier

Abstract

Diagnosis and prognosis of inflammatory bowel disease (IBD)—a chronic inflammation that affects the gastrointestinal tract of patients—are challenging, as most clinical symptoms are not specific to IBD, and are often seen in other inflammatory diseases, such as intestinal infections, drug-induced colitis, and monogenic diseases. To date, there is no gold-standard test for monitoring IBD. Endoscopy and imaging are essential diagnostic tools that provide information about the disease’s state, location, and severity. However, the invasive nature and high cost of endoscopy make it unsuitable for frequent monitoring of disease activity in IBD patients, and even when it is possible to replace endoscopy with imaging, high cost remains a concern. Laboratory testing of blood or feces has the advantage of being non-invasive, rapid, cost-effective, and standardizable. Although the specificity and accuracy of laboratory testing alone need to be improved, it is increasingly used to monitor disease activity or to diagnose suspected IBD cases in combination with endoscopy and/or imaging. The literature survey indicates a dearth of summarization of biomarkers for IBD testing. This review introduces currently available non-invasive biomarkers of clinical importance in laboratory testing for IBD, and discusses the trends and challenges in the IBD biomarker studies.

Funder

Atlanta VA Medical Center

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Reference123 articles.

1. Crohn's disease

2. Ulcerative colitis

3. Ulcerative Colitis and Colorectal Cancer

4. Current management of inflammatory bowel disease and colorectal cancer;Mattar;Gastrointest Cancer Res.,2011

5. Colorectal cancer in inflammatory bowel disease: review of the evidence

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