Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review-Reference-Cited by-同舟云学术

Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review

Published:2024-09-02 Issue:9 Volume:12 Page:1994
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Alberti Adriano¹²,Araujo Coelho David Richer³^ORCID,Vieira Willians Fernando⁴⁵⁶^ORCID,Moehlecke Iser Betine⁷^ORCID,Lampert Rose Meiry Fernandez¹,Traebert Eliane¹,Silva Bruna Becker da¹,Oliveira Bruna Hoffmann de¹^ORCID,Leão Graziela Marques¹,Souza Gabriela de¹,Dallacosta Fabiana Meneghetti⁸,Kades Gabriela⁸,Madeira Kristian⁹^ORCID,Chupel Matheus Uba¹⁰,Grossl Fernando Schorr⁸,Souza Renan⁸,Hur Soares Ben¹¹^ORCID,Endrigo Ruppel da Rocha Ricelli¹²,da Silva Sipriano Erica⁹,Fernandes Martins Daniel¹,Agostinetto Lenita²^ORCID

Affiliation:

1. Department of Biological and Health Sciences Program in Health Sciences, University of Southern Santa Catarina (UNISUL), Palhoça 88132-260, Brazil

2. Graduate Program in Environment and Health, University of Planalto Catarinense—UNIPLAC, Lages 88509-900, Brazil

3. Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA

4. Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo 5508-000, Brazil

5. Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas 13083-864, Brazil

6. Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas 13045-755, Brazil

7. Department of Biological and Health Sciences Posgraduate Program in Health Sciences, University of Southern Santa Catarina (UNISUL), Tubarão 88704-900, Brazil

8. Department of Biosciences and Health, University of West Santa Catarina, Joaçaba 89600-000, Brazil

9. Department of Mathematics and Health Sciences, University of the Extreme South of Santa Catarina (UNESC), Criciúma 88806-000, Brazil

10. Hurvitz Brain Sciences, Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada

11. Department of Physical Education and Physiotherapy, University of Passo Fundo, Passo Fundo 99052-900, Brazil

12. Department of the Graduate Program in Development and Society—PPGEDS (UNIARP), University of Alto Vale do Rio do Peixe, Caçador 89500-199, Brazil

Abstract

Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology of depression is complex and influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated with the development of depression, with a particular focus on the role of obesity. The literature search was conducted on PubMed, Embase, and PsycINFO from May to July 2024. The review highlights the impact of environmental and socioeconomic conditions; lifestyle choices, including physical activity and dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical and psychological conditions; hormone fluctuations; and epigenetic factors on depression. A key emphasis is placed on the inflammatory processes linked to obesity, which may drive the bidirectional relationship between obesity and depression. The findings suggest that obesity is associated with an increased risk of depression, potentially due to chronic inflammation, neurochemical dysregulation, and the emotional and social challenges related to weight stigma and obesity management. Understanding these interconnected factors is important for developing targeted interventions to address both obesity and depression, leading to improved quality of life for those affected.

Funder

São Paulo Research Foundation

National Scientific and Technological Development Council

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-9059/12/9/1994/pdf

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