Affiliation:
1. School of Medicine, Yichun University, Yichun 336000, China
2. School of Pharmacy, Nanchang University, Nanchang 330006, China
Abstract
Nanoscale metal–organic frameworks (nMOFs) have gained increasingly more attention as attractive support materials in the immobilization and delivery of proteins for disease theranostics in recent years owing to their various advantages, such as large specific surface areas, well-ordered pore structures, aperture channel distributions, and ease of functionalization. Here, we present an overview of recent progress in nMOF–protein composites for disease theranostics. First, advantages and construction strategies of nMOF–protein composites as drug carriers are introduced. Then, therapeutic modalities and theranostic nanosystems based on nMOF–protein composites are reviewed. Next, we pay specific attention to their biosafety, biodistribution, and excretion in vivo. Finally, the challenges and limitations of nMOF–protein composites for biomedical applications are discussed, along with future perspectives in the field.
Funder
Project of Jiangxi Provincial Department of public health
Science and Technology Projects of Jiangxi Provincial Department of Education
Subject
Inorganic Chemistry,Condensed Matter Physics,General Materials Science,General Chemical Engineering
Reference73 articles.
1. Introduction to current and future protein therapeutics: A protein engineering perspective;Carter;Exp. Cell Res.,2011
2. Therapeutic proteins;Dimitrov;Methods Mol. Biol.,2012
3. Protein Therapeutic Formulation Issues;Flanagan;Genet. Eng. Biotechnol. News,2010
4. Protein nanoparticles for therapeutic protein delivery;Estrada;Biomater. Sci.,2015
5. Engineering therapeutic protein disaggregases;Shorter;Mol. Biol. Cell,2016