Affiliation:
1. SINOPEC Research Institute of Petroleum Processing Co., Ltd., Beijing 100083, China
2. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
Abstract
Based on the importance of polymorphic regulation, the molecular mechanism of nucleation has been widely concerned. This review begins by introducing the development and limitations of nucleation theory for organic small molecule crystals, followed by a summary of the general research mentality adopted by current researchers. Moreover, the progress of the molecular mechanism of polymorphic nucleation and its application to the regulation of crystal forms are discussed. In addition, the development of scientific tools for the study of the molecular mechanism of polymorphic nucleation is also summarized, including experimental characterization and computational simulation, providing reference for relevant researchers. Finally, according to the main defects of current research and research ideas, research models and development directions of prospects and recommendations are put forward.
Funder
National Engineering Research Center for Petroleum Refining Technology and Catalyst
National Key Research and Development Program of China
Subject
Inorganic Chemistry,Condensed Matter Physics,General Materials Science,General Chemical Engineering
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