Design and Performance Analysis of Perovskites Unidimensional Photonic Crystal-Based Biosensors for Extracellular Vesicles Detection: A Numerical Investigation

Abstract

In recent years, unidimensional photonic crystal-based biosensors have attracted significant attention due to their potential for label-free bio-detection of cells, proteins, and other organic molecules. These biosensors are based on alternating materials with different refractive indices and a cavity region in which biomolecules can be injected. In this study, we investigated numerically the optical properties of unidimensional photonic crystals based on [LiTaO3/MgF2], [LiTaO3/SiO2], [PbTiO3/MgF2], and [PbTiO3/SiO2] heterostructures, and focused our discussion on the detection of four kinds of extracellular vesicles. Our results demonstrated that the [PbTiO3/MgF2] photonic crystal biosensor exhibited the best biosensing performance, with a maximum value of the sensitivity of 511.3 nm/RIU. This study provides valuable insights into the use of perovskites materials, in particular, LiTaO3 and PbTiO3 for photonic crystal-based biosensors for various applications, including disease diagnosis and monitoring therapy responses.