Trajectories of Body Mass Index and Waist Circumference in Relation to the Risk of Cardiac Arrhythmia: A Prospective Cohort Study

Author:

Zhang Liming1,Chen Shuohua2,Cao Xingqi1,Yu Jiening1,Yang Zhenqing1ORCID,Abdelrahman Zeinab3,Yang Gan1,Wang Liang4,Zhang Xuehong5,Zhu Yimin6ORCID,Wu Shouling2,Liu Zuyun1

Affiliation:

1. Second Affiliated Hospital, and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China

2. Department of Cardiology, Kailuan General Hospital, Hebei United University, Tangshan 063000, China

3. Centre for Public Health, Queen’s University of Belfast, Belfast BT12 6BA, UK

4. Department of Public Health, Robbins College of Human Health and Sciences, Baylor University, Waco, TX 76711, USA

5. Department of Nutrition, Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA

6. Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China

Abstract

Background: The aim of the current study was to explore the trajectories, variabilities, and cumulative exposures of body mass index (BMI) and waist circumference (WC) with cardiac arrhythmia (CA) risks. Methods: In total, 35,739 adults from the Kailuan study were included. BMI and WC were measured repeatedly during the 2006–2010 waves. CA was identified via electrocardiogram diagnosis. BMI and WC trajectories were fitted using a group-based trajectory model. The associations were estimated using Cox proportional hazards models. Results: We identified four stable trajectories for BMI and WC, respectively. Neither the BMI trajectories nor the baseline BMI values were associated with the risk of CA. Compared to the low-stable WC group, participants in the high-stable WC group had a higher risk of CA (hazard ratio (HR) = 1.40, 95% confidence interval (CI): 1.06, 1.86). Interestingly, the cumulative exposures of BMI and WC instead of their variabilities were associated with the risk of CA. In the stratified analyses, the positive associations of the high-stable WC group with the risk of CA were found in females only (HR = 1.98, 95% CI: 1.02, 3.83). Conclusions: A high-stable WC trajectory is associated with a higher risk of CA among Chinese female adults, underscoring the potential of WC rather than BMI to identify adults who are at risk.

Funder

Research Center of Prevention and Treatment of Senescence Syndrome, School of Medicine Zhejiang University

“Pioneer” and “Leading Goose” R&D Programs of Zhejiang Province

Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province

Publisher

MDPI AG

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