Abstract
Rational vaccination against and immunotherapy of any infectious disease requires knowledge of how protective and non-protective immune responses differ, and how immune responses are regulated, so their nature can be controlled. Strong Th1 responses are likely protective against M tuberculosis. Understanding how immune class regulation is achieved is pertinent to both vaccination and treatment. I argue that variables of infection, other than PAMPs, primarily determine the class of immunity generated. The alternative, non-PAMP framework I favour, allows me to propose strategies to achieve efficacious vaccination, transcending host and pathogen genetic variability, to prevent tuberculosis, and personalised protocols to treat disease.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference92 articles.
1. In search of a new paradigm for protective immunity to TB;Booty;Nat. Rev. Microbiol.,2014
2. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens;Surcel;Immunology,1994
3. The spectrum of human tuberculosis;Lenzini;Clin. Exp. Immunol.,1977
4. Approaching the asymptote? Evolution and revolution in immunology;Janeway;Cold Spring Harb. Symp. Quant. Biol.,1989
5. Tolerance, danger, and the extended family;Matzinger;Annu. Rev. Immunol.,1994
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献