Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates

Author:

Schiller Emily A.1ORCID,Cohen Koral1,Lin Xinhua1,El-Khawam Rania2,Hanna Nazeeh12ORCID

Affiliation:

1. Department of Foundational Medicine, New York University Long Island School of Medicine, Mineola, NY 11501, USA

2. Department of Pediatrics, Division of Neonatology, New York University Langone Long Island Hospital, Mineola, NY 11501, USA

Abstract

Neonates born prematurely (<37 weeks of gestation) are at a significantly increased risk of developing inflammatory conditions associated with high mortality rates, including necrotizing enterocolitis, bronchopulmonary dysplasia, and hypoxic-ischemic brain damage. Recently, research has focused on characterizing the content of extracellular vesicles (EVs), particularly microRNAs (miRNAs), for diagnostic use. Here, we describe the most recent work on EVs-miRNAs biomarkers discovery for conditions that commonly affect premature neonates.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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