1. Department of Oral Diagnosis and Medicine, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan
2. Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8686, Japan
3. Department of Orthodontics, Keiyu-kai Sapporo Hospital, Sapporo 060-0061, Japan
4. Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Izunokini 410-2321, Japan
5. Department of Oral Surgery, Center Hospital, National Center for Global Health and Medicine, Tokyo 162-8655, Japan