Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review-Reference-Cited by-同舟云学术

Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review

Published:2023-01-25 Issue:3 Volume:24 Page:2358
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Lominadze Zurabi¹^ORCID,Hill Kareen²,Shaik Mohammed Rifat³,Canakis Justin P.⁴,Bourmaf Mohammad²,Adams-Mardi Cyrus⁴,Abutaleb Ameer⁵,Mishra Lopa⁶,Shetty Kirti¹

Affiliation:

1. Division of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

2. Department of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA

3. Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA

4. Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

5. Department of Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

6. Cold Spring Harbor Laboratory, Feinstein Institutes for Medical Research, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, NY 11030, USA

Abstract

The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation.

Funder

NIAAA

NCI

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/3/2358/pdf

Reference103 articles.

1. Ferlay, J.E.M., Lam, F., Colombet, M., Mery, L., and Piñeros, M. (2023, January 02). All Cancers Fact Sheet. Available online: https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf.

2. Epidemiology and Management of Hepatocellular Carcinoma;Kulik;Gastroenterology,2019

3. U.S. Cancer Statistics Working Group (2022, September 11). Cancer Statistics Data Visualizations Tool, Based on 2021 Submission Data (1999–2019): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, Available online: www.cdc.gov/cancer/dataviz.

4. A global view of hepatocellular carcinoma: Trends, risk, prevention and management;Yang;Nat. Rev. Gastroenterol. Hepatol.,2019

5. (2018). EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J. Hepatol., 69, 182–236.

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Indication of Liver Transplant for HCC: Current Status and Future Directions;Current Hepatology Reports;2024-02-22

2. Downstaging Hepatocellular Carcinoma before Transplantation;Surgical Oncology Clinics of North America;2024-01

3. Liver transplantation and liver resection as alternative treatments for primary hepatobiliary and secondary liver tumors: Competitors or allies?;Hepatobiliary & Pancreatic Diseases International;2023-12

4. Sequential regorafenib or nivolumab therapy in recurrent hepatocellular carcinoma with sorafenib failure in liver transplant patients does not improve prognosis;Annals of Liver Transplantation;2023-11-30

5. Hepatocellular Carcinoma: The Role of Immunotherapy and Transplantation in the Era of Transplant Oncology;Cancers;2023-10-24