Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review-Reference-Cited by-同舟云学术

Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review

Published:2023-01-25 Issue:3 Volume:24 Page:2358
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Lominadze Zurabi¹^ORCID,Hill Kareen²,Shaik Mohammed Rifat³,Canakis Justin P.⁴,Bourmaf Mohammad²,Adams-Mardi Cyrus⁴,Abutaleb Ameer⁵,Mishra Lopa⁶,Shetty Kirti¹

Affiliation:

1. Division of Gastroenterology & Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

2. Department of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA

3. Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA

4. Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

5. Department of Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

6. Cold Spring Harbor Laboratory, Feinstein Institutes for Medical Research, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, NY 11030, USA

Abstract

The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation.

Funder

NIAAA

NCI

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/3/2358/pdf

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