Affiliation:
1. Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
2. Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy
Abstract
Thyroid cancer is the most common endocrine cancer, and its incidence is increasing in many countries around the world. Among thyroid cancers, the papillary thyroid cancer (PTC) histotype is particularly prevalent. A small percentage of papillary tumors is associated with metastases and aggressive behavior due to de-differentiation obtained through the epithelial–mesenchymal transition (EMT) by which epithelial thyroid cells acquire a fibroblast-like morphology, reduce cellular adhesion, increase motility and expression of mesenchymal proteins. The tumor microenvironment plays an important role in promoting an aggressive phenotype through hypoxia and the secretion of HMGB1 and other factors. Hypoxia has been shown to drastically change the tumor cell phenotype and has been associated with increasing metastatic and migratory behavior. Cells transfer information to neighboring cells or distant locations by releasing extracellular membrane vesicles (EVs) that contain key molecules, such as mRNAs, microRNAs (miRNAs), and proteins, that are able to modify protein expression in recipient cells. In this study, we investigated the potential role of EVs released by the anaplastic cancer cell line CAL-62 in inducing a malignant phenotype in a papillary cancer cell line (BCPAP).
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference48 articles.
1. Thyroid Cancer;Cabanillas;Lancet,2016
2. Ancker, O.V., Krüger, M., Wehland, M., Infanger, M., and Grimm, D. (2019). Multikinase Inhibitor Treatment in Thyroid Cancer. Int. J. Mol. Sci., 21.
3. Worldwide Increasing Incidence of Thyroid Cancer: Update on Epidemiology and Risk Factors;Pellegriti;J. Cancer Epidemiology,2013
4. Differentiated Thyroid Cancer: Management of Patients with Radioiodine Nonresponsive Disease;Busaidy;J. Thyroid. Res.,2012
5. Treatment Outcomes of Differentiated Thyroid Cancer with Distant Metastasis Improve by Tyrosine Kinase Inhibitors;Iwasaki;Oncol. Lett.,2019
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献