A Comprehensive Review of mRNA Vaccines-Reference-Cited by-同舟云学术

A Comprehensive Review of mRNA Vaccines

Published:2023-01-31 Issue:3 Volume:24 Page:2700
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Gote Vrinda¹^ORCID,Bolla Pradeep Kumar²^ORCID,Kommineni Nagavendra³^ORCID,Butreddy Arun⁴^ORCID,Nukala Pavan Kumar⁵^ORCID,Palakurthi Sushesh Srivatsa⁶,Khan Wahid⁷^ORCID

Affiliation:

1. Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri, 2464 Charlotte Street, Kansas City, MO 64108, USA

2. Department of Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W University Ave, El Paso, TX 79968, USA

3. Center for Biomedical Research, Population Council, New York, NY 10065, USA

4. Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA

5. College of Pharmacy and Health Sciences, St. John’s University, 8000 Utopia Pkwy, Queens, NY 11439, USA

6. Department of Pharmaceutical Sciences, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX 78363, USA

7. Natco Research Centre, NATCO Pharma Limited, Hyderabad 500018, India

Abstract

mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to emerging as COVID-19 pandemic vaccine front-runners. The advancements in the field of nanotechnology for developing delivery vehicles for mRNA vaccines are highly significant. In this review we have summarized each and every aspect of the mRNA vaccine. The article describes the mRNA structure, its pharmacological function of immunity induction, lipid nanoparticles (LNPs), and the upstream, downstream, and formulation process of mRNA vaccine manufacturing. Additionally, mRNA vaccines in clinical trials are also described. A deep dive into the future perspectives of mRNA vaccines, such as its freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also summarized.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/3/2700/pdf

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