Affiliation:
1. Moscow Regional Research and Clinical Institute (MONIKI) Named after M.F. Vladimirskiy, 129110 Moscow, Russia
2. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
Abstract
Laser-based medical techniques for evaluating blood flow (BF), such as laser Doppler flowmetry, laser speckle contrast imaging, etc., are known, but expensive and have some disadvantages. Recently, we have proposed a new technique—incoherent optical fluctuation flowmetry (IOFF), which is realized using a LED-based optical probe. This work aims to theoretically study the dependence of BF registered by IOFF on the source-detector distance (SDD) in the probe. For this purpose, we developed a three-layer optical model of skin and used Monte Carlo (MC) simulations of light propagation. All computations were performed for a wavelength of 810 nm and several SDDs from 1 to 14 mm. MC results showed that the BF depends nonlinearly on the SDD. Herewith, the BF is strongly correlated with the mean photon path length in a tissue (R = 0.92). Thus, flowmeters with different SDDs can give different BF values on the same patient. Based on the study results, to standardize BF measurements, it has been justified that BF magnitudes measured should be normalized to the exponential function of the SDD in the used optical probe in the form of [1 − exp(−b·SDD)], where b is a constant.
Funder
Russian Science Foundation
Subject
Radiology, Nuclear Medicine and imaging,Instrumentation,Atomic and Molecular Physics, and Optics
Cited by
1 articles.
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