Polycationic Photosensitizers as Effective Anticancer Agents That Destroy Cancer Stem Cells, Cancer Vascularization and Induce Protective Desmoplastic Reaction around Lung Cancers-Reference-Cited by-同舟云学术

Polycationic Photosensitizers as Effective Anticancer Agents That Destroy Cancer Stem Cells, Cancer Vascularization and Induce Protective Desmoplastic Reaction around Lung Cancers

Published:2024-05-21 Issue:6 Volume:11 Page:485
ISSN:2304-6732
Container-title:Photonics
language:en
Short-container-title:Photonics

Author:

Kogan Evgeniya¹,Meerovich Gennady²³,Karshieva Saida⁴⁵,Makarova Elena⁶^ORCID,Romanishkin Igor²^ORCID,Akhlyustina Ekaterina³,Meerovich Irina⁷,Zharkov Nikolay⁸^ORCID,Kharnas Sergey⁹,Levkin Vladimir⁹,Demura Sofya¹,Chen Zhilong¹⁰,Loschenov Victor²³,Reshetov Igor¹¹

Affiliation:

1. Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia

2. Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia

3. Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI, Moscow 115409, Russia

4. N.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia

5. Research and Educational Center of Biomedical Engineering, National University of Science and Technology MISIS, Moscow 119049, Russia

6. Organic Intermediates and Dyes Institute, Moscow 123001, Russia

7. A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia

8. Center of Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia

9. N.V. Sklifosovskiy Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia

10. Huadong Hospital, Fudan University, Shanghai 200433, China

11. L.L. Levshin Institute of Cluster Oncology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia

Abstract

PDT using PSs based on polycationic derivatives of synthetic bacteriochlorin against Lewis lung carcinoma provides effective inhibition of tumor growth with an increase in the lifespan and survival of mice in the group. PDT with polycationic photosensitizers destroys CSCs and tumor neovascularization, and activates the desmoplastic reaction. These results open up new opportunities for increasing the effectiveness of treatment and reducing the incidence of relapses and metastases after PDT.

Funder

Russian Science Foundation

National Natural Science Foundation of China

Publisher

MDPI AG

Link

https://www.mdpi.com/2304-6732/11/6/485/pdf

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