Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751

Author:

Yu Jiaming1ORCID,Guo Hui2ORCID,Zhang Jing3,Hu Jiansen24,He Hongtao2,Chen Caixia56,Yang Na2ORCID,Yang Fan3,Lin Zexu1,Dai Huanqin2,Ouyang Liming1ORCID,Liu Cuihua2ORCID,Lei Xiaoguang3ORCID,Zhang Lixin12,Zhu Guoliang1ORCID,Song Fuhang27ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

3. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

5. Technology Transfer Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

6. School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA

7. Key Laboratory of Geriatric Nutrition and Health, Ministry of Education of China; School of Light Industry, Beijing Technology and Business University, Beijing 100048, China

Abstract

A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Ministry of Science and Technology of China

Publisher

MDPI AG

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