Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751-Reference-Cited by-同舟云学术

Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751

Published:2024-06-03 Issue:6 Volume:22 Page:259
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Yu Jiaming¹^ORCID,Guo Hui²^ORCID,Zhang Jing³,Hu Jiansen²⁴,He Hongtao²,Chen Caixia⁵⁶,Yang Na²^ORCID,Yang Fan³,Lin Zexu¹,Dai Huanqin²,Ouyang Liming¹^ORCID,Liu Cuihua²^ORCID,Lei Xiaoguang³^ORCID,Zhang Lixin¹²,Zhu Guoliang¹^ORCID,Song Fuhang²⁷^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

3. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

5. Technology Transfer Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

6. School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA

7. Key Laboratory of Geriatric Nutrition and Health, Ministry of Education of China; School of Light Industry, Beijing Technology and Business University, Beijing 100048, China

Abstract

A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Ministry of Science and Technology of China

Publisher

MDPI AG

Link

https://www.mdpi.com/1660-3397/22/6/259/pdf

Reference33 articles.

1. WHO (2023). Global Tuberculosis Report 2023, World Health Organization.

2. Emerging novel and antimicrobial-resistant respiratory tract infections: New drug development and therapeutic options;Zumla;Lancet Infect. Dis.,2014

3. Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis;Bloemberg;N. Engl. J. Med.,2015

4. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019;Newman;J. Nat. Prod.,2020

5. Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as antitubercular prodrugs;Wang;Angew. Chem. Int. Ed.,2013