Affiliation:
1. School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
2. Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China
Abstract
Developing novel, safe, and efficient proangiogenic drugs is an important approach for the prevention and treatment of cardiovascular diseases. In this study, 4 new compounds, including 3 azaphilones (1–3) and 1 dihydroisocoumarin (4), as well as 13 known compounds (5–17), were isolated from the sea-mud-derived fungus Neopestalotiopsis sp. HN-1-6 from the Beibu Gulf of China. The structures of the new compounds were determined by NMR, MS, ECD, and NMR calculations. Compounds 3, 5, and 7 exhibited noteworthy proangiogenic activities in a zebrafish model at a concentration of 40 μM, without displaying cytotoxicity toward five human cell lines. In addition, some compounds demonstrated antibacterial effects against Staphylococcus aureus, Escherichia coli, and Candida albicans, with MIC values ranging from 64 μg/mL to 256 μg/mL.
Funder
Key Research and Development Project of Hainan Province
Specific Research Project of Guangxi for Research Bases and Talents
Natural Science Foundation of China
Talent Scientific Research Initiation Project of Guangxi Minzu University
Xiangsi Lake Youth Innovation Team Project of Guangxi Minzu University
National Natural Science Foundation of China
Guangxi Scholarship Fund of Guangxi Education Department