Affiliation:
1. Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
2. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Abstract
Four new cyclic pentapeptides, avellanins D–G (1–4), together with four known compounds (5–8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus from Acanthus ilicifolius L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey’s method. Compounds 1–8 were screened for insecticidal and antibacterial activities. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with an LC50 value of 86.6 µM; compound 4 had weak activity against Vibrio harveyi with an MIC value of 5.85 µM.
Funder
Natural Science Foundation of Guangxi
Guangxi Key Research and Development Programme
Guangxi Province Natural Science Foundation of Innovative Research Team Project
The Development Program of High-level Talent Team under the Qihuang Project of Guangxi University of Chinese Medicine
Guangxi University of Chinese Medicine “GuiPai Traditional Chinese Medicine inheritance and innovation team” Project
Guangxi Natural Science Foundation Project
Guangdong-Guangxi Joint Fund—Key project
Reference26 articles.
1. Hafez Ghoran, S., Taktaz, F., Ayatollahi, S.A., and Kijjoa, A. (2022). Anthraquinnoes and their analogues from marine-derived fungi: Chemistry and biological activities. Mar. Drugs, 20.
2. Cyclosporin A—A review on fermentative production, downstream processing and pharmacological applications;Survase;Biotechnol. Adv.,2011
3. Predicting and defining vancomycin efficacy: Program overview;Moellering;Clin. Infect. Dis.,2006
4. New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics;Bills;Nat. Prod. Rep.,2014
5. A current perspective on daptomycin for the clinical microbiologist;Humphries;Clin. Microbiol. Rev.,2013