The Antidiabetic Potential of Probiotics: A Review

Author:

Li Shiming12,Liu Zichao1,Zhang Qi1,Su Dan3,Wang Pengjie1ORCID,Li Yixuan1,Shi Wenbiao1ORCID,Zhang Qian1

Affiliation:

1. Department of Nutrition and Health, China Agricultural University, Beijing 100193, China

2. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100193, China

3. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA

Abstract

Diabetes has become one of the most prevalent global epidemics, significantly impacting both the economy and the health of individuals. Diabetes is associated with numerous complications, such as obesity; hyperglycemia; hypercholesterolemia; dyslipidemia; metabolic endotoxemia; intestinal barrier damage; insulin-secretion defects; increased oxidative stress; and low-grade, systemic, and chronic inflammation. Diabetes cannot be completely cured; therefore, current research has focused on developing various methods to control diabetes. A promising strategy is the use of probiotics for diabetes intervention. Probiotics are a class of live, non-toxic microorganisms that can colonize the human intestine and help improve the balance of intestinal microbiota. In this review, we summarize the current clinical studies on using probiotics to control diabetes in humans, along with mechanistic studies conducted in animal models. The primary mechanism by which probiotics regulate diabetes is improved intestinal barrier integrity, alleviated oxidative stress, enhanced immune response, increased short-chain fatty acid production, etc. Therefore, probiotic supplementation holds great potential for the prevention and management of diabetes.

Funder

Beijing Nova Program

National Natural Science Foundation of China

Beijing Natural Science Foundation

111 Project from the Education Ministry of China

Chinese Universities Scientific Fund

Publisher

MDPI AG

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