A Metabolomics and Big Data Approach to Cannabis Authenticity (Authentomics)
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Published:2023-05-03
Issue:9
Volume:24
Page:8202
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Jadhav Pramodkumar D.1ORCID, Shim Youn Young123ORCID, Paek Ock Jin4, Jeon Jung-Tae5, Park Hyun-Je56, Park Ilbum5, Park Eui-Seong5, Kim Young Jun3ORCID, Reaney Martin J. T.123ORCID
Affiliation:
1. Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada 2. Prairie Tide Diversified Inc., Saskatoon, SK S7J 0R1, Canada 3. Department of Food and Biotechnology, Korea University, Sejong 30019, Republic of Korea 4. Herbal Medicines Research Division, Ministry of Food and Drug Safety, Cheongju 28159, Republic of Korea 5. Yuhan Care R&D Center, Yuhan Care Co., Ltd., Yongin 17084, Republic of Korea 6. Yuhan Natural Product R&D Center, Yuhan Care Co., Ltd., Andong 36618, Republic of Korea
Abstract
With the increasing accessibility of cannabis (Cannabis sativa L., also known as marijuana and hemp), its products are being developed as extracts for both recreational and therapeutic use. This has led to increased scrutiny by regulatory bodies, who aim to understand and regulate the complex chemistry of these products to ensure their safety and efficacy. Regulators use targeted analyses to track the concentration of key bioactive metabolites and potentially harmful contaminants, such as metals and other impurities. However, the metabolic complexity of cannabis metabolic pathways requires a more comprehensive approach. A non-targeted metabolomic analysis of cannabis products is necessary to generate data that can be used to determine their authenticity and efficacy. An authentomics approach, which involves combining the non-targeted analysis of new samples with big data comparisons to authenticated historic datasets, provides a robust method for verifying the quality of cannabis products. To meet International Organization for Standardization (ISO) standards, it is necessary to implement the authentomics platform technology and build an integrated database of cannabis analytical results. This study is the first to review the topic of the authentomics of cannabis and its potential to meet ISO standards.
Funder
Ministry of SMEs and Startups
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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