Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes-Reference-Cited by-同舟云学术

Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes

Published:2023-05-05 Issue:9 Volume:24 Page:8275
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Ścieżyńska Aneta¹²,Łuszczyński Krzysztof¹,Radziszewski Marcin¹^ORCID,Komorowski Michał¹^ORCID,Soszyńska Marta¹,Krześniak Natalia³,Shevchenko Kateryna¹,Lutyńska Anna²,Malejczyk Jacek¹^ORCID

Affiliation:

1. Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland

2. Department of Medical Biology, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 04-628 Warsaw, Poland

3. Department of Plastic and Reconstructive Surgery, Medical Centre of Postgraduate Education, Prof. W. Orlowski Memorial Hospital, 00-416 Warsaw, Poland

Abstract

The ABCA4 gene encodes an ATP-binding cassette transporter that is expressed specifically in the disc of photoreceptor outer segments. Mutations in the ABCA4 gene are the main cause of retinal degenerations known as “ABCA4-retinopathies.” Recent research has revealed that ABCA4 is expressed in other cells as well, such as hair follicles and keratinocytes, although no information on its significance has been evidenced so far. In this study, we investigated the role of the ABCA4 gene in human keratinocytes and hair follicle stem cells for the first time. We have shown that silencing the ABCA4 gene increases the deleterious effect of all-trans-retinal on human hair follicle stem cells.

Funder

National Science Centre

Medical University of Warsaw

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/9/8275/pdf

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