The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer-Reference-Cited by-同舟云学术

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Published:2023-05-05 Issue:9 Volume:24 Page:8325
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Magkrioti Christiana¹,Kaffe Eleanna¹²,Aidinis Vassilis¹^ORCID

Affiliation:

1. Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece

2. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA

Abstract

Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a secreted enzyme with lysophospholipase D activity, with its primary function being the extracellular hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid [...]

Funder

Hellenic Foundation for Research and Innovation

HFRI

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/9/8325/pdf

Reference55 articles.

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3. ATX expression and LPA signalling are vital for the development of the nervous system;Fotopoulou;Dev. Biol.,2010

4. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid;Tanaka;J. Biol. Chem.,2006

5. Yukiura, H., Kano, K., Kise, R., Inoue, A., and Aoki, J. (2015). Autotaxin overexpression causes embryonic lethality and vascular defects. PLoS ONE, 10.

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