Dysregulated Inflammatory Cytokine Levels May Be Useful Markers in a Better Up-Dated Management of COVID-19
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Published:2024-08-15
Issue:8
Volume:46
Page:8890-8902
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ISSN:1467-3045
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Container-title:Current Issues in Molecular Biology
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language:en
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Short-container-title:CIMB
Author:
Iuliano Marco1ORCID, Mongiovì Roberta Maria2, Parente Alberico3, Kertusha Blerta3, Carraro Anna3ORCID, Marocco Raffaella3, Mancarella Giulia3, Del Borgo Cosmo3, Fondaco Laura3, Grimaldi Lorenzo1, Dorrucci Maria4, Lichtner Miriam5ORCID, Mangino Giorgio1ORCID, Romeo Giovanna1ORCID
Affiliation:
1. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy 2. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98122 Messina, Italy 3. Department of Public Health and Infectious Disease, S. Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy 4. Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy 5. Department of General Surgery and Surgical Specialty, Sapienza University of Rome, 00168 Rome, Italy
Abstract
Coronavirus disease 2019 (COVID-19) is an infection characterized by the dysregulation of systemic cytokine levels. The measurement of serum levels of inflammatory cyto-/chemokines has been suggested as a tool in the management of COVID-19. The aim of this study is to highlight the significance of measured levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12(p70), IL-27, interferon (IFN)γ, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and tumor necrosis factor (TNF)-α in serum samples from infected and recovered subjects, possibly predictive of severity and/or duration of the disease. Serum samples from healthy (HD), positive at hospital admittance (T0), and recovered subjects (T1, 31–60, or 70–200 days post-negativization) were collected and tested through a bead-based cytometric assay and confirmed through ELISA. IL-10 levels were increased in the T0 group compared to both HD and T1. IL-27 significantly decreased in the 31–60 group. IL-1β significantly increased in the 70–200 day group. TNF-α significantly decreased in T0 compared to HD and in the 31–60 group versus HD. IP-10 significantly increased in T0 compared to HD. These results suggest that IP-10 could represent an early marker of clinical worsening, whereas IL-10 might be indicative of the possible onset of post-COVID-19 long syndrome.
Funder
MUR—“Fondo Integrativo Speciale per la Ricerca”
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