Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells-Reference-Cited by-同舟云学术

Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells

Published:2024-07-23 Issue:8 Volume:46 Page:7782-7794
ISSN:1467-3045
Container-title:Current Issues in Molecular Biology
language:en
Short-container-title:CIMB

Author:

Lee I-Yun¹²^ORCID,Wang Ting-Chung³^ORCID,Kuo Yu-Jen³,Shih Wei-Tai¹²^ORCID,Yang Pei-Rung¹²,Hsu Cheng-Ming⁴⁵⁶^ORCID,Lin Yu-Shih⁷⁸,Kuo Ren-Shyang¹,Wu Ching-Yuan¹²

Affiliation:

1. Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

2. School of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

3. Department of Neurosurgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

4. Department of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

5. School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

6. Cancer Center, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

7. Department of Pharmacy, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

8. Institute of Molecular Biology, National Chung Cheng University, Chiayi 62102, Taiwan

Abstract

Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug metformin on apoptosis and ferroptosis were compared. Furthermore, the combination treatment of APS and metformin was also investigated. We found that APS not only reduced the growth of lung cancer cells but also had a synergistic effect with metformin on A549 cells. The study results showed that it may be promising to use APS and metformin as a combination therapy for the treatment of lung adenocarcinoma.

Funder

Chang Gung Memorial Hospital

Publisher

MDPI AG

Link

https://www.mdpi.com/1467-3045/46/8/461/pdf

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