Abstract
This study aimed to compare Korean smokers’ smoking-related biomarker levels by tobacco product type, including heat-not-burn cigarettes (HNBC), liquid e-cigarettes (EC), and traditional cigarettes (TC). Nicotine dependence levels were evaluated in Korean adult study participants including TC-, EC-, HNBC-only users and nonsmokers (n = 1586) from March 2019 to July 2019 in Seoul and Cheonan/Asan South Korea using the Fagerström Test Score. Additionally, urine samples (n = 832) were collected for the measurement of urinary nicotine, cotinine, OH-cotinine, NNAL(4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), CYMA(N-acetyl-S-(2-cyanoehtyl)-L-cysteine), or CEMA (2-cyanoethylmercapturic acid) using LC–MS/MS. The median(interquartile range) nicotine dependence level was not different among the three types of smokers, being 3.0 (2.0–5.0) for TC- (n = 726), 3.0 (1.0–4.0) for EC- (n = 316), and 3.0 (2.0–4.0) for HNBC- (n = 377) only users. HNBC-only users presented similar biomarker levels compared to TC-only users, except for NNAL (HNBC: 14.5 (4.0–58.8) pg/mL, TC: 32.0 (4.0–69.6) pg/mL; p = 0.0106) and CEMA (HNBC: 60.4 (10.0–232.0) ng/mL, TC: 166.1 (25.3–532.1) ng/mL; p = 0.0007). TC and HNBC users showed increased urinary cotinine levels as early as the time after the first smoke of the day. EC users’ biomarker levels were possibly lower than TC or HNBC users’ but higher than those of non-smokers.
Funder
Korea Center for Desease Control and Prevention
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference43 articles.
1. Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults
2. WHO Report on the Global Tobacco Epidemic
https://www.who.int/tobacco/surveillance/policy/country_profile/kor.pdf?ua=1
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