Author:
Prabdial-Sing Nishi,Motaze Villyen,Manamela Jack,McCarthy Kerrigan,Suchard Melinda
Abstract
As South Africa transitions from endemic to intermediate endemicity, hepatitis A surveillance needs strengthening to monitor trends in disease incidence and to identify outbreaks. We used passive laboratory-based surveillance data from the National Health Laboratory Services to calculate national hepatitis A incidence and to establish thresholds for outbreaks. Incidence was calculated by age and geographic location. The static threshold used two or three standard deviations (SDs) above the mean hepatitis A incidence in 2017–2019, and a cumulative summation (CuSum2) threshold used three SDs above the mean of the preceding seven months. These thresholds were applied to hepatitis A data for 2020. From 2017 to 2020, the mean incidence of hepatitis A IgM was 4.06/100,000 and ranged from 4.23 to 4.85/100,000 per year. Hepatitis A incidence was highest in the Western Cape province (WCP) (7.00–10.92/100,000 per year). The highest incidence was in the 1–9-year-olds. The incidence of hepatitis A in 2020 exceeded the static threshold in two districts of the WCP: Cape Winelands in January and Overberg district in August. The provincial incidence did not exceed the static and CuSum2 thresholds. District-level analysis using either threshold was sensitive enough to monitor trends and to alert district health authorities, allowing early outbreak responses.
Subject
Virology,Infectious Diseases
Reference33 articles.
1. Plan of Action for the Prevention and Control of Viral Hepatitishttps://www.paho.org/hq/dmdocuments/2016/2016-cha-plan-action-prev-hep-en.pdf
2. WHO Position Paper on Hepatitis A Vaccineshttp://www.who.int/wer
3. Update on global epidemiology of viral hepatitis and preventive strategies
4. Hepatitis Ahttps://www.who.int/news-room/fact-sheets/detail/hepatitis-a
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献