The Impact of Alcohol Consumption Pattern on Liver Fibrosis in Asymptomatic Patients
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Published:2023-11-29
Issue:23
Volume:12
Page:7405
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Minea Horia12, Singeap Ana-Maria12ORCID, Sfarti Catalin Victor12ORCID, Girleanu Irina12ORCID, Chiriac Stefan12ORCID, Muzica Cristina12ORCID, Cuciureanu Tudor12ORCID, Petrea Oana Cristina12ORCID, Huiban Laura12, Zenovia Sebastian12ORCID, Nastasa Robert12ORCID, Rotaru Adrian12ORCID, Stafie Remus12ORCID, Stratina Ermina12ORCID, Cojocariu Camelia12ORCID, Stanciu Carol12, Trifan Anca12ORCID
Affiliation:
1. Department of Gastroenterology, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania 2. Institute of Gastroenterology and Hepatology, “St. Spiridon” University Hospital, 700111 Iasi, Romania
Abstract
Introduction: Alcohol consumption (AC) represents a widespread cause of liver diseases affecting 10–20% of the population. The study aimed to evaluate the relationship between advanced liver fibrosis (ALF) measured by transient elastography (TE), laboratory parameters, and the amount of AC depending on non-modifiable risk factors such as age and gender. Methods: We examined 689 patients with an average age of 49.32 ± 14.31 years, 72.9% males, without liver pathology, who admitted a moderate/high consumption (female ≤ 7 versus > 7 drinks/week; male ≤ 14 versus > 14 drinks/week) for at least five years. The fibrosis level was adjusted according to transaminase levels. Predictive factors were established using univariate regression analysis. Results: ALF (≥F3) was detected in 19.30% of subjects, predominantly males (14.1%) and patients over 55 years (12.5%). Excessive consumption of distilled spirits is associated with ALF in females (OR = 4.5), males (OR = 6.43) and patients over 55 years (OR = 3.73). A particularity highlighted in both genders, regardless of the age group, was the negative correlation between the decrease in the number of platelets, the albumin concentration, and the appearance of AFL. Conclusions: Screening using TE represents an approach for early detection of ALF in asymptomatic populations and the development of a risk stratification scheme.
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