A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression-Reference-Cited by-同舟云学术

A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression

Published:2023-06-30 Issue:7 Volume:45 Page:5613-5630
ISSN:1467-3045
Container-title:Current Issues in Molecular Biology
language:en
Short-container-title:CIMB

Author:

Sharlo Kristina A.¹^ORCID,Lvova Irina D.¹,Tyganov Sergey A.¹^ORCID,Sergeeva Ksenia V.¹,Kalashnikov Vitaly Y.¹,Kalashnikova Ekaterina P.¹,Mirzoev Timur M.¹^ORCID,Kalamkarov Grigoriy R.²,Shevchenko Tatiana F.²,Shenkman Boris S.¹

Affiliation:

1. Myology Laboratory, Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia

2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia

Abstract

Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous rat soleus muscle electrical activity under unloading conditions. In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

Link

https://www.mdpi.com/1467-3045/45/7/354/pdf

Reference40 articles.

1. Electromyography of rat soleus, medical gastrocnemius, and tibialis anterior during hind limb suspension;Alford;Exp. Neurol.,1987

2. Effects of Physical Activity and Inactivity on Muscle Fatigue;Bogdanis;Front. Physiol.,2012

3. Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury;Boulenguez;Nat. Med.,2010

4. Bouviere, J., Fortunato, R.S., Dupuy, C., Werneck-De-Castro, J.P., Carvalho, D.P., and Louzada, R.A. (2021). Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle. Antioxidants, 10.

5. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling;Braz;J. Clin. Investig.,2003

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1. Molecular Signaling Effects behind the Spontaneous Soleus Muscle Activity Induced by 7-Day Rat Hindlimb Suspension;International Journal of Molecular Sciences;2024-07-30

2. The Effect of Spontaneous Neuromuscular Activity on the Development of Atrophy of the Functionally Unloaded <i>m. soleus</i>;Российский физиологический журнал им И М Сеченова;2023-10-01