Squalene Peroxidation and Biophysical Parameters in Acne-Prone Skin: A Pilot “In Vivo” Study

Author:

Condrò Giorgia1,Sciortino Roberta1,Perugini Paola12ORCID

Affiliation:

1. Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy

2. Etichub, Academic Spin-Off, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy

Abstract

Nowadays, acne vulgaris therapies are often unsuccessful. One of the responsible factors for the formation of comedones and inflammatory lesions could be the peroxidation of squalene, a hydrocarbon representing one of the major components of human sebum. This peroxidation is increased by solar irradiation. The purpose of this work was to set up an in vivo method for the extraction and quantification of squalene from acne skin and to correlate the results with biophysical skin parameters such as sebum amount, protein content and TEWL. Healthy volunteers were used as control. The results obtained demonstrated that acne-prone skin had a major quantity of squalene, and, in the stratum corneum area, its peroxide form is present. Moreover, Spearman’s rank correlation showed a positive correlation between sebum content and peroxide squalene and between porphyrin intensity and peroxide squalene.

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference32 articles.

1. Management of acne vulgaris with trifarotene;Tan;J. Cutan. Med. Surg.,2023

2. Condrò, G., Guerini, M., Castello, M., and Perugini, P. (2022). Acne vulgaris, atopic dermatitis and rosacea: The Role of the Skin Microbiota—A Review. Biomedicines, 10.

3. Acne vulgaris;Makrantonaki;Nat. Rev. Dis. Primers,2015

4. Sebum analysis of individuals with and without acne;Pappas;Dermato. Endocrinol.,2009

5. Therapeutic applications of squalene—A review;Gopakumar;Fish. Technol.,2012

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