Therapeutic Potential of Kappa Opioid Agonists

Author:

Beck Tyler C.ORCID,Hapstack Matthew A.,Beck Kyle R.,Dix Thomas A.ORCID

Abstract

Many original research articles have been published that describe findings and outline areas for the development of kappa-opioid agonists (KOAs) as novel drugs; however, a single review article that summarizes the broad potential for KOAs in drug development does not exist. It is well-established that KOAs demonstrate efficacy in pain attenuation; however, KOAs also have proven to be beneficial in treating a variety of novel but often overlapping conditions including cardiovascular disease, pruritus, nausea, inflammatory diseases, spinal anesthesia, stroke, hypoxic pulmonary hypertension, multiple sclerosis, addiction, and post-traumatic cartilage degeneration. This article summarizes key findings of KOAs and discusses the untapped therapeutic potential of KOAs in the treatment of many human diseases.

Funder

National Institute on Drug Abuse

National Institute of Neurological Disorders and Stroke

The National Institute of Mental Health

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference68 articles.

1. Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

2. The Kappa Opioid Receptor Takes Shapehttps://www.painresearchforum.org/news/93114-kappa-opioid-receptor-takes-shape

3. Peripherally Restricted Opioid Agonists as Novel Analgesic Agents

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