The Effects of Systemic Vitamin D Level on the Healing of Different Graft Materials: An Experimental Histological Study

Author:

Hacibektasoglu Mehmet Sefa1ORCID,Balcioglu Huseyin Avni2,Uyanikgil Yigit3ORCID,Balcioglu Nilufer Bolukbasi1ORCID

Affiliation:

1. Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Istanbul 34093, Turkey

2. Department of Anatomy, Faculty of Medicine, Health Sciences University, Istanbul 34716, Turkey

3. Department of Histology and Embryology, Faculty of Medicine, Ege University, Izmir 35030, Turkey

Abstract

The aim of this study is to investigate the effects of serum vitamin D levels on the healing of different bone graft materials. Thirty-six male rats were divided into three groups and fed special feeds containing different amounts of vitamin D for 6 weeks before the surgical phase: the high serum vitamin D level group (group H) 10,000 iu/kg vitamin D3; the standard serum vitamin D level group (group C) 1000 iu/kg D3; and the low-level vitamin D group (group L) 100 iu/kg vitamin D3. Under general anesthesia, four defects with a diameter of 5 mm were created in the calvaria of the rats. The defects were augmented with autogenous grafts, allografts, xenografts, or left empty. The serum vitamin D level was measured before the surgery and before sacrifice. At the end of the 6th week, the subjects were sacrificed, and histological and histomorphometric analyses were performed. Study results show that in all graft types, as vitamin D levels increase, the number of new bone formations increases. There was no significant difference between the graft materials in terms of new bone formation criteria in group L. In group H and group C, the highest new bone formation was seen in the allograft group (1.48 ± 0.07, 0.66 ± 0.19, respectively). Prospective randomized clinical studies are required to evaluate the effect of vitamin D dose on the success of augmentation procedures in the clinic.

Funder

Scientific Research Projects Coordination Unit of Istanbul University

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

Reference18 articles.

1. Bone augmentation techniques;McAllister;J. Periodontol.,2007

2. Phylogenetic and evolutionary aspects of vitamin D from phytoplankton to humans;Holick;Vertebr. Endocrinol. Fundam. Biomed. Implic.,1989

3. A millenium perspective Vitamin D;Holick;J. Cell. Biochem.,2003

4. High prevalence of vitamin D inadequacy and implications for health;Holick;Mayo Clinic Proceedings,2006

5. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease;Holick;Am. J. Clin. Nutr.,2004

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