Design and Manufacture of a Test Device for Radiosynthesizer Vacuum Pumps

Author:

Amador Diaz Victor1ORCID,Snyder Scott E.2,Vavere Amy L.1

Affiliation:

1. Molecular Imaging Core, Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA

2. Molecular Imaging Ligand Development Program, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Abstract

Vacuum pump wear is the most prevalent failure mode of the IBA Synthera® automated radiochemistry system. Rebuilding or replacing the pump causes equipment downtime and increases the radiation exposure of the service personnel. We built a dedicated test device to assess new or rebuilt pumps prior to installation, thus reducing downtime and radiation exposure during repairs. The Testbed incorporates a microprocessor that actuates the pump, valves, and pressure sensor; communicates with the user through lights, buttons, and an alphanumeric screen; and outputs test results to a laptop. The Testbed increases productivity and safety in the radiochemistry laboratory.

Funder

ALSAC-St. Jude Children’s Research Hospital

Publisher

MDPI AG

Subject

Instrumentation

Reference10 articles.

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3. Pfeiffer Vacuum GmbH (2023, April 03). Vacuum Technology and Know How. Available online: https://www.pfeiffer-vacuum.com/en/know-how/container!download.action?referer=1456&download=/filepool/file/literature/vacuum-technology-book-ii-part-2.pdf.

4. High beam current operation of a PETtraceTM cyclotron for 18F−Production;Eberl;Appl. Radiat. Isot.,2012

5. (2023, April 03). Current Good Manufacturing Practice for Positron Emission Tomography Drugs, 21 C.F.R. §212.60, Available online: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=212.60.

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